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In patients with chronic obstructive pulmonary diseaseCOPDclinical studies have shown that theophylline decreases dyspneaair trappingthe work of breathingand improves contractility of diaphragmatic muscles with little or no improvement in pulmonary function measurements.
Quibron-T is a xanthine derivativeIt works by relaxing the muscle around the airways in the lungswhich allows them to widen and makes breathing easierIt also improves contraction of the diaphragmthe major breathing muscleand decreases the response of the airways to irritants.
AminoglutethimidebarbituratesegphenobarbitalcarbamazepinehydantoinsegphenytoinisoproterenolmoricizinerifampinStJohn’s wortor sulfinpyrazone because they may decrease Quibron-T’s effectiveness Allopurinolbeta-blockersegpropranololcimetidinedisulfiramenoxacinestrogenfebuxostatfluvoxamineinterferon alphamacrolide antibioticsegclarithromycinerythromycinmethotrexatemexiletineoral contraceptivesbirth control pillspentoxifyllinepropafenonequinolone antibioticsegciprofloxacintacrinethiabendazoleticlopidinetroleandomycinverapamilviloxazineor zileuton because they may increase the risk of Quibron-T’s side effects Ephedrine because the risk of side effectssuch as nauseanervousnessand trouble sleepingmay be increased Halothane because the risk of side effects such as irregular heartbeat may be increased Ketamine because the risk of seizures may be increased Adenosinebenzodiazepinesegdiazepamflurazepamlorazepammidazolamdipyridamole IVlithiumor nondepolarizing muscle relaxantsegpancuroniumbecause their effectiveness may be decreased by Quibron-T.
Do not crush or chew the capsules or tabletsDoing so can release all of the drug at onceincreasing the risk of side effectsAlsodo not split the tablets unless they have a score line and your doctor or pharmacist tells you to do soSwallow the whole or split tablet without crushing or chewing.
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